This paper proposes a 2.4 GHz active mixer without passive inductor for the transceiver system. Taking into account the design requirements of the mixer, a double-balanced down-conversion structure with active inductor and negative resistance is designed. The proposed mixer with 130 nm CMOS technology is designed and simulated using Cadence software at 1.5 V supply voltage. Although we had to compromise conversion gain with linearity, we were able to achieve very high conversion gain with average linearity. Based on the results of post-layout simulations, the conversion gain of 27.57 dB, IIP3 equal to -7.88 dBm, 1-dB compression point equal to -17.34 dBm and IIP2 equal to 44.22 dBm with power consumption of 2.5 mW was obtained for the proposed mixer. The chip size without input and output pads is 95.18 µm × 117.68 µm, which leads to a chip area of 0.0112mm2.

The present article using alination as a theoretical concept and based on empirical data obtained from a survey research on student alinaton in Tehran universities, attempts to offer a conceptual and operational definition of the term social -cultural alination (value isolation) in order to measure students degree of value isolation. Using a causal- descriptive model, value isolation has been assumed to be affected by sereval independent variables. The major goals of the research were two -fold: first, to determine the correlational associations between value isolation and socio -psychological variables. A second goal was to compare and contrast the behavioral characteristics of the alinated students in Iran with those in other countries in order to delineate similarities and differences in students behavioral patterns as well as testing the validity of theoretical concept. The findings revealed a significant relationship between alination (value isolation) of students and their SES , life satisfaction, social control, Oedipal conflict with authoritarian parents and hostility toward society. The value and behavioral patterns expressed by alienated students in Iran correlated with and revealed similarities to those in other communities. The study, however, poses many additional questions of value isolation to be raised.

Background: Tetralogy of Fallot (TOF) refers to a condition in which left ventricular volume is normal or slightly less than normal. Given the differences observed in some Asian patients with TOF، the present study was conducted to investigate left heart by determining Z-scores for the mitral valve in Iranian patients with TOF. Methods: Eligible subjects in this prospective descriptive study comprised all patients with TOF presenting to Shahid Modarres Hospital in Tehran from March 2012 to March 2015 and diagnosed as the candidates for surgery. After determining the need for surgery and the therapeutic method required، the mitral valve size and Z-scores were calculated. We analyzed sex، age، body surface area (BSA)، mitral size (in 2-chamber and 4-chamber view)، mitral Z-score، other cardiac anomalies، number of surgery and previous surgery. Results: Of a total of 80 patients included in the study over 3 years، 29 (36. 3%) were male and 51 (63. 8%) were female. The mean age of the patients was 7. 15± 3. 37 years and their mitral size was found to be 10-27 mm (16. 2± 5. 99 mm) using echocardiography. Z-scores of the mitral valve were also obtained as-3. 09± 2. 11، ranging between-7. 1 SD and +1. 3 SD. 58 (72. 5%) patients have only TOF and 22 (27. 5%) with other cardiac anomalies. 45 patients were for first time underwent surgery and 22 patients for second time، 12 patients for three time and 1 for forth. Of a total of 35 patients had previous surgery، the most common were shunt 15 (42. 9%) and then tetralogy of Fallot total correction (TFTC) in 12 (34. 3%). Of a total of 80 patients، 59 (73. 8%) underwent TFTC، 17 (21. 3%) under pulmonary valve replacement and 4 (5%) shunt. Conclusion: Z-scores of the mitral valve were found to be significantly below the normal value، (i. e. 0± 2 SD)، in the study patients، suggesting the risk of hypoplastic left heart syndrome in Iranian patients with TOF، nevertheless، the type of TOF examined in these patients might have been different from those observed in other races and regions.

Supercritical Fluid Extraction (SFE) has emerged as a green and sustainable technique for isolating high-value bioactive compounds from natural sources. This method leverages the unique properties of supercritical fluids, particularly supercritical carbon dioxide (SC-CO2), to enhance the selectivity, efficiency, and environmental sustainability of the extraction process. Compared with traditional methods that use solvents, SFE has several benefits, such as leaving behind very little solvent, causing less damage to heat-sensitive compounds, and improving the amount extracted. This review provides a comprehensive overview of the principles of SFE, including thermodynamics, phase behaviour, and selection of supercritical fluids. Furthermore, it highlights the optimization parameters that influence extraction efficiency, such as pressure, temperature, co-solvent use, and flow rate. The applications of SFE in the recovery of phytochemicals, essential oils, nutraceuticals, and marine-derived bioactive compounds are discussed, with emphasis on its role in the pharmaceutical, food, and cosmetic industries. Additionally, this review explores recent advancements in SFE technology, including its integration with other green extraction methods and novel equipment designs, while addressing the challenges associated with industrial-scale implementation. Finally, future perspectives on enhancing the efficiency, cost-effectiveness, and sustainability of SFE are outlined, reinforcing its potential as a key technology in green extraction science.

Application and interpretation of statistical significance of association are the basic and necessary principle in medical research. Traditionally, hypothesis testing and reporting p-values are widely used to quantify the statistical significance of observed results. In the last two decades, the calculation of a p-value in research and especially the use of a threshold to declare the statistical significance of the p-value have been challenged. The limitations of p-value, such as the dependence of its value on the sample size and not reflecting the clinical significance, have been repeatedly mentioned. The statisticians and methodologists recommend do not report p-value alone, and reporting of effect size index with corresponding confidence interval is mandatory. However, many researchers do not pay attention to this and do not even interpret the p-value correctly. The present study intended, to provide an integrated instruction for reporting the statistical and clinical significance in medical sciences with the approach of hypothesis testing (reporting p-value).

Introduction: The expected values of hematologic and serum biochemical parameters in domestic animal species can be affected by breed, age, environment, and nutrition. Established breed-specific reference intervals (RI) are an important tool for monitoring the health of sheep. There is a lack of published data on biochemical RI for Sngsari sheep. Thus, the aims of this study were to establish RI for select of serum biochemical parameters for Sangsari sheep by Reference Value Advisor (RVA) method and provide information on the studied parameters for both sex of this breed in order to form a basis for clinical interpretation. Materials and Methods: Sixty healthy Sangsari sheep including 26 ewes and 34 rams (2– 4 years old) were chosen from the breeding station of Sangsari sheep among 150 sheep in Damghan, Semnan, Iran. The type of feeding, all the animals had free access to water and to good-quality alfalfa hay (90. 0 % DM, 15. 8 CP % DM, 50. 4NDF%DM, 31. 6ADF%DM, 5. 8 lignin% DM, and 2. 2 EE % DM). Concentrate (23 % oats, 36 % corn, 38 % barley, and 3%mineral and vitamin supplements) was provided once daily (200 g per animal per day). In the sampling day, breeder signed a subscription form and completed a primary questionnaire consisting of specific questions about past and current health status, sexual status, medications used, and familial and reproductive medical history. Complete physical examinations were performed by the same experienced veterinarian on each sheep. In order to reduce stress, blood samples were taken in the station with minimal changes in the usual schedule of the sheep. Blood samples (taken from the jugular vein) were collected in simple tubes in order to separate the serum (centrifuged at 3000 rpm for 10 min) for biochemical analysis. Samples transported at +4 ° C to the laboratory department of the Faculty of Veterinary Medicine, Semnan, Iran. Biochemical parameters were measured by a autoanalyzer. These parameters included alkaline phosphatase (ALP), gamma glutamyletransferase (GGT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), total protein (TP) and albumin (Alb). For statistical analysis, data were analyzed by Reference Value Advisor and outliers were deleted if detected according to Tukey or Dixon. RIs, according to sample size, were determined using a robust method and following Box-Cox transformation of data. The data were normally distributed, and differences between sexes in biochemical parameters were analyzed using independent sample T test. A value of P<0. 05 was considered as significant. Results and Discussion: The RI of biochemical parameters obtained from adult healthy Sangsari sheep includes the following: ALP 49. 24-564. 84 u/l; GGT 24. 14-62. 23 u/l; AST 10. 86-338. 40 u/l; BUN 6. 91-26. 43 mg/dl; TP 5. 19-13. 95 gr/dl and Alb 0. 92-3. 63 gr/dl. Established RI of biochemical parameters for ewes and rams, respectively including: ALP 29. 98-702. 89 u/l; GGT 22. 41-54. 49 u/l; AST 1. 36-279. 89 u/l; BUN 5. 9526. 86 mg/dl; TP 5. 75-12. 83 gr/dl; Alb 0. 84-2. 77 gr/dl and ALP 106. 08-568. 55 u/l; GGT 20. 80-58. 30 u/l; AST 360. 12 u/l; BUN 8. 15-26. 04 mg/dl; TP 4. 66-15. 59 g/dl and Alb 0. 74-3. 77 g/dl. Interpretation of the biochemical results in different breeds of sheep, with regard to RI for each parameter, in conjunction with history, clinical findings and other paraclinical tests helps the clinician to reach a definitive diagnosis. A unique feature of Sangsari sheep is that they are highly adaptable with desert and mountain ranges with high tolerance of drought conditions. This breed is also relatively small size and light weight, and most studies have focused on genetic characteristics associated with this trait. In view of the characteristics mentioned above and considering the lack of reference range for biochemical parameters, it is necessary to determine reference intervals in Sangsari sheep. In order to establish a comprehensive reference interval in Sangsari sheep, a select biochemical parameters were evaluated in the present study. Almost most of the established RI for biochemical parameters in this study differed from previously published RI, so that the lower and upper limits of RI of theses parameters (with the exception of BUN) were lower and higher than the values previously reported. Differences between obtained RI for the Sangsari sheep and previously reported RI for other breeds may be attributed to variations in hormonal influences, hydration status, dietary differences, or adaptations to a desert environment, age, breed, season of study and analytic method. Conclusion: The obtained data provided reference interval for biochemical parameters in Sangsari sheep for the first time. Present study demonstrates significant differences in most of the biochemical parameters. Reference intervals determined in this study provide a baseline for interpreting biochemical results in Sangsari sheep, and contribute to optimization of the management of this species.